Adipocyte-derived lipids modulate CD4+T-cell function

How PI3K-derived lipids control cell division

To succeed in cell division, intense cytoskeletal and membrane remodeling are required to allow accurate chromosome segregation and cytoplasm partitioning. Spatial restriction of the actin dynamics and vesicle trafficking define the cell symmetry and equivalent membrane scission events, respectively. Protein complexes coordinating mitosis are recruited to membrane microdomains characterized by ...

Specific microRNAs modulate ES cell-derived neurogenesis

MicroRNAs (miRNAs) are recently discovered small non-coding transcripts with a broad spectrum of functions described mostly in invertebrates. As post-transcriptional regulators of gene expression, miRNAs trigger target mRNA degradation or translational repression. While hundreds of miRNAs have been cloned from a variety of mammalian tissues and cells, and multiple mRNA targets have been predict...

Metabolism of lipids in human white adipocyte.

Adipose tissue is considered as the body's largest storage organ for energy in the form of triacylglycerols, which are mobilized through lipolysis process, to provide fuel to other organs and to deliver substrates to liver for gluconeogenesis (glycerol) and lipoprotein synthesis (free fatty acids). The release of glycerol and free fatty acids from human adipose tissue is mainly dependent on hor...

Katherine G . Langley Endogenous , Adipocyte - Derived Lipids Signal the Recruitment of Proin fl ammatory Immune Cells

Obesity, insulin resistance, and type 2 diabetes have reached epidemic levels in Western countries. Work over the past decade has established that the adipose tissue in obesity is characterized by a state of chronic, low-grade inflammation, which plays a primary role in the development of systemic insulin resistance (1). Critical to the development of adipose tissue inflammation in obesity is t...

Stromal Cells Modulate Monocyte Function Umbilical Cord-Derived Mesenchymal